My headcanon… After the explosion in the destroy ending Shepard’s body is found in the rubble. Her entire left side of her body is badly burned and her arm and leg have to be replaced with prosthetic ones. She is in a coma and remains that way for like… 8 months or something. Then she wakes up in a very under-staffed coma ward and limps around looking for anyone familiar.
When she doesn’t find anyone and realizes how much her muscles have weakened from her months in a vegetative state. She breaks down, remembering everything that happened and realizing that shes weak, broken and alone…. But she doesn’t realize Garrus just went downstairs to get something to eat. Dude was hungry.